![]() ![]() In conclusion, elevated level of CRP may be a valuable early marker in predicting the possibility of disease progression in non‐severe patients with COVID‐19, which can help health workers to identify those patients an early stage for early treatment. ![]() Thus, CRP production is induced by inflammatory cytokines and by tissue destruction in patients with COVID‐19. Cytokines fight against the microbes but when the immune system becomes hyperactive, it can damage lung tissue. The elevated levels of CRP might be linked to the overproduction of inflammatory cytokines in severe patients with COVID‐19. CRP levels are correlated well with the severity of symptoms of patients with COVID‐19 therefore, it may be a suitable marker in assessing a patient's conditions together with other clinical findings. So, higher levels of CRP indicate more severe disease course‐linked to lung injury and worse prognosis. Indicating that more severe patients with lung damage have elevated levels of CRP. The authors also noted that the risk of developing severe events is increased by 5% for every one‐unit increase in CRP concentration in patients with COVID‐19.įurthermore, it was observed that patients with low oxygen saturation (SpO 2 ≤ 90%) had significantly higher levels of CRP (median 76.5 mg/L) compared with patients with high oxygen saturation (SpO 2 > 90%) (median 12.7 mg/L), A significant association was observed between CRP concentrations and the aggravation of non‐severe patients with COVID‐19, and the authors proposed CRP as a suitable marker for anticipating the aggravation probability of non‐severe COVID‐19 patients, with an optimal threshold value of 26.9 mg/L. The patients who died from COVID‐19 had about 10 fold higher levels of CRP than the recovered patients (median 100 vs 9.6 mg/L).Ī recent study showed that about 7.7% of non‐severe COVID‐19 patients were progressed to severe disease courses after hospitalization,Īnd compared to non‐severe cases, the aggravated patients had significantly higher concentrations of CRP (median 43.8 vs 12.1 mg/L). In another study, the mean concentration of CRP was significantly higher in severe patients (46 mg/L) than non‐severe patients (23 mg/L). For example, a study reported that patients with more severe symptoms had on average CRP concentration of 39.4 mg/L and patients with mild symptoms CRP concentration of 18.8 mg/L.ĬRP was found at increased levels in the severe group at the initial stage than those in the mild group. Patients with severe disease courses had a far elevated level of CRP than mild or non‐severe patients. A significant increase of CRP was found with levels on average 20 to 50 mg/L in patients with COVID‐19.Įlevated levels of CRP were observed up to 86% in severe COVID‐19 patients. ![]() ![]() The available studies that have determined serum concentration of CRP in patients with COVID‐19 are presented in Table 1. When the inflammation or tissue damage is resolved, CRP concentration falls, making it a useful marker for monitoring disease severity. This binding makes active the classical complement pathway of the immune system and modulates the phagocytic activity to clear microbes and damaged cells from the organism. CRP preferably binds to phosphocholine expressed highly on the surface of damaged cells. In blood, the normal concentration of CRP is less than 10 mg/L however, it rises rapidly within 6 to 8 hours and gives the highest peak in 48 hours from the disease onset.Īnd its concentration decreases when the inflammatory stages end and the patient is healing. Of these clinical parameter, serum C‐reactive protein (CRP) has been found as an important marker that changes significantly in severe patients with COVID‐19.ĬRP is a type of protein produced by the liver that serves as an early marker of infection and inflammation. Clinical studies demonstrated that altered levels of some blood markers might be linked with the degree of severity and mortality of patients with COVID‐19. Therefore, it is important to early identify and give the treatment of this subset of patients to reduce the disease severity and improve the outcomes of COVID‐19. However, there is an emerging challenge that a small subset of mild or non‐severe COVID‐19 patients develops into a severe disease course. Severe patients with COVID‐19 are generally treated in the intensive care unit, while mild or non‐severe patients treated in the usual isolation ward of the hospital. The healthcare workers are facing challenges in reducing the severity and mortality of COVID‐19 across the world. The outbreak of coronavirus disease‐2019 (COVID‐19) is an emerging global health threat. ![]()
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